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Two-Year Effects of Semaglutide in Adults with Overweight or Obesity (STEP 5) Nature Medicine Participants receiving semaglutide 2.4 mg weekly maintained 15.2% body weight loss at 104 weeks, with significant improvements in cardiometabolic risk factors including waist circumference and HbA1c

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If additional trials confirm that they effectively curb cravings across addictive substances, these drugs could begin to close one of the most consequential treatment gaps in medicine